South East Asia Journal of Medical Sciences <div id="journalDescription"> <div id="journalDescription"> <div id="journalDescription"> <div id="coverJOSI"><img style="/* width: 5%; */float: left; width: 119px; margin-right: 1.2em; text-align: left;" src="" alt="SEAJMS" /></div> <div> <p style="background-color: #fffdf7; padding: 5px 10px; border-bottom: 3px solid #ffba39; font-size: 0.9em;"><strong>Title:</strong> South East Asia Journal of Medical Sciences<br /><strong>ISSN:</strong> <a href="" target="_blank" rel="noopener">2522-7165</a> (online), <a href="" target="_blank" rel="noopener">2520-7342</a> (print)<br /><strong>Indexed at: </strong><a href="" target="_blank" rel="noopener">ROAD</a>, <a href=";type=all&amp;oaboost=1&amp;ling=1&amp;name=&amp;thes=&amp;refid=dcresen&amp;newsearch=1" target="_blank" rel="noopener">Base</a>, <a href="" target="_blank" rel="noopener">PKP Index</a>, <a href=";qt=results_page" target="_blank" rel="noopener">OCLC WorldCat</a><br /><strong>Citation:</strong> <a href=";as_sdt=0%2C5&amp;;oq=" target="_blank" rel="noopener">Google Scholar</a><br /><strong>Archive Preservation:</strong> <a href="" target="_blank" rel="noopener">The Keepers (PKP PN)</a><br /><strong>OAI:</strong> <a href="" target="_blank" rel="noopener"></a></p> </div> </div> </div> </div> en-US <p>The authors agreed following terms while submitting the article:</p> <ol type="a"> <ol type="a"> <li>Coauthors and I retain copyright and grant the journal right of first publication with the work and also agree that, if accepted by the editorial team, shall be licensed under a <a href="" rel="license">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a> (Articles can be shared and adapted, provided the attribution for the work is given and that the work is not used for commercial purposes), full details of which can be found <a href="">here.</a></li> <li>I, on behalf of myself and my co-authors, authorize that: <ul> <li>​​the article is original and was not published in any other peer-reviewed journal, and is not under consideration by any other journal, and does not violate any existing copyright or any other third party rights.</li> </ul> </li> </ol> </ol> (Journal Office) (Support) Wed, 31 May 2023 05:00:46 +0000 OJS 60 The Power of Computational Chemogenomics and In Silico Tools for Drug Discovery Ambadasu Bharatha, Kandamaran Krishnamurthy Copyright (c) 2023 Ambadasu Bharatha, Kandamaran Krishnamurthy Wed, 31 May 2023 00:00:00 +0000 Triple co-infection involving Dengue Fever, Scrub Typhus and Acute Brucellosis - a rare and surprising entity <p>&nbsp;</p> <p>We report a case of a 28 year old patient presenting with the chief complaints of fever attributed to multiple co-infections. Co-infections have been infrequently reported in literature, dual co-infections being the most common variety. Dengue Fever, Scrub typhus and Acute Brucellosis are commonly found in North India, however they have never been reported to occur simultaneously in the same patient. Cross-reactivity amongst the tests for these infections is unlikely as well. This highlights the possibility of the multiple co-infections in patients presenting with mixed or un-improving symptoms as well as those with laboratory values disproportionate to each tropical illness. Physicians should hold high index of suspicion for co-infections if the same is noted in patients with fever.</p> Naveen Rajput, Ritika Abrol, Manasvi Kalra Copyright (c) 2023 NAVEEN RAJPUT, RITIKA ABROL, Manasvi Kalra Thu, 27 Apr 2023 00:00:00 +0000 Keeping Up with the Times: The Importance of Staying Current in Scientific Publishing <p><strong>Editorial</strong></p> Ambadasu Bharatha Copyright (c) 2023 Sun, 01 Jan 2023 00:00:00 +0000 Back pain in an elderly patient - A case report <p style="font-weight: 400;"><strong>ABSTRACT</strong></p> <p style="font-weight: 400;">Low back pain (LBP) secondary to the degenerative spinal disorder is a very common medical condition that presents in elderly people and rarely indicates a serious illness. We would like to report a case of 83 years old gentleman with a history of chronic degenerative back pain with the change in the nature of back pain, which triggered us to arrange further investigations and diagnosed Psoas abscess(PA) secondary to septic vertebral arthritis. It was treated with CT-guided drainage and sensitive antibiotics. This case report highlights the atypical presentation of diseases in elderly patients, and the common pitfalls of missing serious pathologies, which increases morbidity and mortality.</p> <p style="font-weight: 400;"><em><strong>Keywords</strong></em>:<em> low back pain, septic arthritis, Psoas abscess</em></p> Zay Yar Aung, Nyein Aye Lwin, Diraviyam Balasubramanian Copyright (c) 2023 Zay Yar Aung, Nyein Aye Lwin, Diraviyam Balasubramanian Fri, 06 Jan 2023 00:00:00 +0000 Immunogenicity of a single dose mRNA vaccine in SARS-CoV-2 exposed subjects: A systematic review <p><strong>Background:</strong> The novel coronavirus is quickly spreading and mutating, putting the public health and lifestyle in shambles. The development and approval of mRNA vaccines came up as a breakthrough. The breadth of immune response after a single-dose vaccination in the already infected population is discovered for understanding the hybrid immunity and side effects associated with second dose. Administering a single-dose vaccine to the seropositive population can spare the doses for the population at higher risk.</p> <p><strong>Methods:</strong> PubMed, Web of Science, Google scholar, medRxiv and Cochrane library were explored to extract the original data on the efficacy of single-dose mRNA vaccines in seropositive subjects. The Cochrane risk of bias tool was used to assess the risk of bias in the studies.</p> <p><strong>Results:</strong> 6 studies evaluating the immunogenicity of single-dose mRNA vaccine were incorporated along with some observational studies and literature. These studies present promising evidence for administering only single-dose mRNA vaccine in seropositive subjects, providing biphasic immune response of higher breadth and duration.</p> <p><strong>Limitations:</strong> Most studies had a small sample size, did not correlate the results with higher age groups, with potential risk factors and the percentage of individuals who contracted breakthrough infections.</p> <p><strong>Conclusions:</strong> Single-dose mRNA vaccine can be immunogenic and protective enough for already seropositive population by increasing the number of Spike protein-specific memory B-cells. Vaccination schedules based on existing anti-body titers in such individuals can spare doses for vulnerable groups, especially when there is limited production and supply of vaccines worldwide.</p> Jagtar Singh, Seema Thakur Copyright (c) 2022 Jagtar Singh, Seema Thakur Mon, 26 Sep 2022 00:00:00 +0000