Colchicine-induced pancreatitis in an elderly patient with renal impairment: A case report

Author(s)
Shakil Ahmed Chohan(1*), Diraviyam Balasubramanian(2), Thet Thet Soe(3)
(*) Corresponding Author

Abstract

Colchicine is widely used in the treatment of acute gout. It has a narrow therapeutic window and can be extremely toxic in vulnerable older patients especially those with renal impairment. The most common side effects are gastrointestinal related, such as nausea, vomiting, diarrhea and abdominal pain. Colchicine-induced acute pancreatitis is very rare especially within therapeutic dose range. We report an atypical presentation of acute pancreatitis caused by a therapeutic dose of colchicine in an elderly patient with preexisting chronic renal disease.

Keywords

acute pancreatitis, atypical presentation, older person, colchicine-induced, renal impairment

Full Text:

HTML PDF

References

Ting JY. Acute pancreatitis related to therapeutic dosing with colchicine: a case report. J Med Case Rep. 2007 Aug 12;1:64.

Badalov N, Baradarian R, Iswara K, Li J, Steinberg W, Tenner S. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol. 2007 Jun;5(6):648-61; quiz 644. Epub 2007 Mar 28. Review..

Mofenson HC, Caraccio TR, Nawaz H, Steckler G. Acetaminophen induced pancreatitis. J Toxicol Clin Toxicol. 1991;29(2):223-30.

Gilmore IT, Tourvas E. Paracetamol-induced acute pancreatitis. Br Med J. 1977 Mar 19;1(6063):753-4.

Yoshizawa Y, Ogasa S, Izaki S, Kitamura K. Corticosteroid-induced pancreatitis in patients with autoimmune bullous disease: case report and prospective study. Dermatology. 1999;198(3):304-6.

Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981 Aug;30(2):239-45.

Statistics Article Statistics Abstract viewed - 742 times
HTML - 500 times PDF - 185 times

Refbacks

  • There are currently no refbacks.

Copyright (c) 2019 Shakil Ahmed Chohan, Diraviyam Balasubramanian, Thet Thet Soe

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.