Remarkable Hypokalemia among Sudanese Patients with Jaundice
DOI:
https://doi.org/10.5281/zenodo.3723456Abstract
Background: Impairment of potassium levels is common in clinical practice, mainly encountered among hospitalized patients with a wide spectrum of sickness. Hypokalemia is a potentially dangerous irregularity that may have pernicious actuates. Objective: This study was directed to measure the potassium levels in Sudanese infected with jaundice.
Material and Methods: A cross-sectional study recruited in the laboratory center of Port Sudan teaching hospital during the period from the 14th July 2008 to the 5th April 2009. 90 Icteric patients (30 hemolytic Icterus patients, 30 hepatic Icterus patients and 30 obstructive Icterus patients) along with 30 apparently healthy controls were enrolled. Serum potassium and bilirubin levels were evaluated.
Results: Hypokalemia noted in 45 (50%) of the Icterus patients. Hypokalemia was significantly associated with hepatic and obstructive jaundice (P < 0.000). Hypokalemia was strongly positively correlated with conjugated bilirubin concentration (P < 0.000/r = -0.736) and negatively correlated with unconjugated bilirubin concentration (P < 0.078/r = -0.187).
Conclusion: Hypokalemia is predominant in patients with jaundice and may worsen the morbidity of the illness.
Keywords: Serum potassium; Hypokalemia; Jaundice; Sudan.
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References
Lin SH, Huang CL. Mechanism of thyrotoxic periodic paralysis. J Am Soc Nephrol 2012;23(6):985-988.
Zacchia M, Abategiovanni ML, Stratigis S, Capasso G. Potassium: From Physiology to clinical Implications. Kidney Dis (Basel 2016;2(2):72-79.
Wu KL, Cheng CJ, Sung CC, Tseng MH, Hsu YJ, Yang SS, et al. identification of the causes for Chronic Hypokalemia: importance of Urinary Sodium and Chloride Excretion. Am J Med 2017;130(7):846-855.
Ciulla AP, Lehman DC. . Success! in clinical laboratory science: complete review. 4th ed. Pearson Education; 2010.
Liamis G, Liberopoulos E, Barkas F, Elisaf M. Spurious electrolyte disorders: A diagnostic Challenge for Clinicians. Am J Nephrol 2013;38(1):50-57.
Wang L, Yu WF. Obstructive jaundice and Perioperation management. Acta Anesthesiologic Taiwanica 2014;52(1):22-29.
Ahmed I, Amin ZA, Ashraf HM. Determination of factors precipitating encephalopathy in patients with liver cirrhosis. Pak Armed Forces Med J Sep 2006;56(3):284-288.
Abu-Assi S, Vlaeevie ZR. Hepatic encephalo-pathy: metabolic consequences of the cirrhois are often reversible. Post graduate Med 2001;109:80.
Starr SP, Raines, D "Cirrhosis, diagnosis, management, and prevention". 2011;84(12):1353.
Jamali AA, Jamali GM, Jamali AA, Chandio MH, Tanwani BM. Hypokalemia in cirrhotic patients. Indo American Journal of Pharmaceutical Sciences 2018;5(3):1831.
Gaduputi V, Chandrala C, Abbas N, Tariq H, Chilimuri S, Balar B. Prognostic significance of hypokalemia in hepatic encephalopathy. Hepatogastroenterology 2014;61(133):1170.
Mehboob F. Frequency of risk factors for hepatic encephalopathy in patients of chronic liver disease. Ann King Edward Med Coll 2003;9:29-30.
Devrajani BR, Shah SZ, Devrajani T, Kumar D. Precipitating factors of hepatic encephalopathy at a tertiary care hospital Jamshoro, Hyderabad. J Pak Med Assoc 2009;59(10):683-686.
Masood N, Rahopoto Q, Gouri A, Munir A. Precipitating factors of hepatic encephalopathy in patients with cirrhosis of liver. Med channel 2010;16(3):376-379.
Mumtaz K, Ahmed US, Abid S, Baig N, Hamid S, Jafri W. Precipitating factors and the outcome of hepatic encephalopathy in liver cirrhosis. J Coll Physicians Surg Pak 2010;20(8):514-518.
Alam I, Razaullah, Haider I, Humayun M, Taqweem MA, Nisar M. Spectrum of precipitating factors of hepatic encephalopathy in liver cirrhosis. Pakistan J Med Res 2005;44(2):96-100.
Sundaram V, Shaikh OS. Hepatic encephalopathy: pathophysiology and emerging therapies. Med. Clin. North Am 2009;93(4):819.
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